Applying the QTY code to design water-soluble variants of GPCRs.
Four water molecules surround the side chains of glutamine and asparagine, and three water molecules surround the side chains of serine, threonine, and tyrosine.
Water-soluble QTY-variant GPCRs retain form and ligand binding activity in water.
Structural comparison of designed water-soluble GPCRs and native GPCRs, superimposed, distinguished by color.
First discovery of self-assembling peptides in yeast.
From peptides to hydrogels.
From peptide scaffold hydrogel to sustained protein release.
First report of lipid-like peptide nanotubes.
Designed surface self-assembling peptides.
From single peptides to peptide nanofibers to a peptide scaffold.
Pathway to a self-assembling single nanofiber.
Design of lipid-like peptides.
Lipid-like peptide nanotubes.
Neural stem cells in self-assembling peptide nanofiber scaffold.
Neurons forming synapses in peptide scaffold hydrogel.
Details of cells embedded in 3-D self-assembling peptide scaffold.
Human cells producing Type I and Type III collagen in peptide hydrogel scaffold.
Cell migration in three dimensions.
Single peptide to scaffold used for neurons, stem cells, cartilage, bone, and brain tissue repair.